Glaucoma Treatment Simplified

October 9th, 2014  |  The Blog

Glaucoma is the leading cause of irreversible blindness in the world. It is an eye disease in which the ocular pressure is elevated and causes damage to the optic nerve.

The disease is asymptomatic until the end stage when vision is irreversibly diminished. Damage to the optic nerve causes vision loss and blindness.

The key to treating glaucoma is early detection so the proper and effective eye drops can be prescribed and administered to lower the ocular pressure.

Traditional Glaucoma Treatment

Glaucoma is routinely treated by medications, laser treatments and conventional surgery. A brief overview of each approach includes:

  • The medications are usually eye drops but there are some oral medications, as well.
  • The laser surgery helps to drain some fluid from the eye, which will lower the ocular pressure, by burning holes in the backside of the eye. This is done in the doctor?s office or clinic.
  • The conventional surgery is a longer operating room procedure during which an opening is made in the eye to drain fluid and lower the pressure. This is only done when medications and laser surgery have been unsuccessful in treating the patient.

Looking at the Medication Administration-Specifically, Eye Drops

Eye drops like latanoprost or Xalatan are effective in treating glaucoma. They lower the eye pressure and prevent vision loss. These drugs do not reverse glaucoma.

The only way they are truly effective is if the patient is compliant with the drug administration. Poor patient compliance limits the benefits of the drugs. A recent study shows that eye drop compliance in glaucoma patients is only slightly higher than 50%.

The side effects of the drugs like burning and stinging add to the poor compliance rate. Patients cannot sense any positive feedback like pain management or immediately clearer vision after taking the drops so often do not bother to take them.

New Treatment Option

A new treatment option to increase compliance with the eye medications is a contact lens that dispenses latanoprost and other eye medications. Boston Children?s Hospital, in collaboration with the Massachusetts Institute of Technology (MIT) has developed this contact lens concept.

The contact delivers the drugs in a large quantity for a long period of time at a relatively consistent rate, according to the development team at Boston Children?s Hospital.

The contact lens is a pairing of two polymers, which encapsulate the drug and modulate its release into the eye.

The contact lenses will be available in prescription form for those who are near or far sighted. This benefit will also increase compliance.

The U.S. Food and Drug Administration (FDA) do not yet approve this drug-eluting contact lens for use.

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What You Need to Know About Enterovirus D68

October 1st, 2014  |  The Blog

The Enterovirus D68 is usually a rare illness but has seen a rapid increase in cases over the recent weeks, according to the U.S. Centers for Disease Control (CDC).

The Enterovirus D68 was first identified in 1962 in California. Thereafter, it was rarely seen or diagnosed until about 2009 when there were cases reported mostly in Japan, the Philippines and the Netherlands.

Generally, enteroviruses affect 10 to 15 million people in the U.S. every year. These illnesses are typically mild and often without any overt or untoward symptoms.

Who is Affected?

The current Enterovirus D68 respiratory virus is affecting children across the country. The virus started to evolve in the Midwest during the month of August and is spreading east.

The patient population for the Enterovirus D68 (EV-D68) is children and teenagers. The primary group affected by the illness is 2 to 6 year olds. Of those who contract the virus, about 68% have a history of asthma or wheezing.

With the cold and virus season hitting its stride in the month of September, it seems that the EV-68 is taking the lead from the basics of the common cold virus.

The Symptoms of Enterovirus D68

The illness causes a severe respiratory infection, which has required many hospitalizations including admission to intensive care units for some patients.

A runny nose and/or the sniffles do not identify the virus. Difficulty breathing does define EV-D68. It commands immediate medical attention.

The symptoms include:

  • Runny nose
  • Sniffles
  • Congestion
  • Fever
  • Cough
  • Muscle aches
  • Wheezing
  • Difficulty breathing


Most people recuperate from the Enterovirus D68. A few need to be hospitalized but the recent uptick in cases has resulted in more hospitalizations for supportive care. While there is no cure for the illness, oxygen therapy is helpful.


The real prevention of spreading the virus comes with basic infection control common sense around this cold and flu season:

  • Wash hands regularly with soap and water. Use hand sanitizer when soap and water are not available.
  • Do not share cups, straws or utensils.
  • Regularly wash doorknobs, toys and common surfaces like the kitchen and bathroom counters with an antibacterial wipe.
  • Avoid anyone who is sick as much as possible.
  • Teach those around you NOT to use their hands to cover a cough or sneeze; encourage them to do so into the crook of their bent elbow.

Children with asthma need to be sure that it is well controlled during the active virus season. Extra caution should be taken to watch this population closely. It is very important that asthmatics take their daily medications everyday.

If an asthmatic child starts to develop cold-like symptoms, they should be closely monitored and seek medical care if respiratory distress develops.

The Outcome

As of now, there have been no deaths reported due to the illness. Children recuperate from EV-D68, although some have a more difficult road to recovery than others.

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Let’s Talk About Antibiotics

September 24th, 2014  |  The Blog

Let’s talk antibiotics. When needed to treat a bacterial infection, antibiotics are usually curative.

With the season of colds, flus and other contagious illnesses fast approaching, this is a good time to talk about the use and abuse of antibiotics. Everyone moves to inside activities and germs are more readily shared, like it or not.

There is a time and place for antibiotic use and a mission to prevent antibiotic misuse and overuse in the country

Bacteria Explained

Just like all other living organisms, bacteria seek to grow and thrive. So, the more often they are exposed to antibiotics, the more opportunities they have to adapt to them and build up a resistance to them. This renders the antibiotics less effective, especially when they are really needed.

This cycle of exposure and growing resistance due to misuse and overuse of antibiotics leads to the general public’s lowered ability to fight against infections.

When to Use Antibiotics

Antibiotics are meant to treat bacterial infections. Period.

When Not to Use Antibiotics

Antibiotics do not treat viruses. A virus, not bacteria, causes the common cold and most other respiratory infections. Antibiotics will not help in this medical situation.

Problems Created by Antibiotics

Antibiotic resistance is a big and growing public health issue. Over time, this is a situation created by the overuse of antibiotics.

Common side effects of antibiotics can range from an upset stomach and diarrhea to a skin rash. Serious and potentially fatal reactions, from the sloughing skin of Stevens Johnson Syndrome to anaphylaxis, can also occur from antibiotics. Children, taking a new antibiotic for the first time sometimes end up making an emergency room visit due to a bad drug reaction.

Taking leftover antibiotics from a previous illness or someone else’s prescription for antibiotics is a bad decision. Specific antibiotics are prescribed for a specific illness and should not be crossed over with other illnesses or people. This is a dangerous practice.

Unless a prescribed antibiotic prescription is taken as directed and until it is gone, a bacterial infection will not be fully treated. It can recur and/or worsen without the full and proper treatment. Patients must be educated to take the entire prescription of an antibiotic to achieve the intended results.

Interestingly, 50% of prescribed antibiotics, whether inpatient or outpatient, are not indicated or necessary. One major example is the patient who sees their PCP for a common cold and leaves the office with an antibiotic prescription. This is a common occurrence in the general population.

The Bottomline

When antibiotics are indicated, they are a good and proper treatment. When they are unnecessarily prescribed, they create a public health threat of resistant bacteria.

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The Dangers of Sleep Apnea

September 15th, 2014  |  The Blog

Sleep apnea affects all facets of life, by day and by night. It is important to diagnose and treat sleep apnea. Management of the condition improves the quality of life and general wellness.

Sleep apnea studies are traditionally done in a hospital setting. There are sensors, electrodes, microphones and infrared cameras involved in the process. Sleep technicians monitor the patient throughout the process, which can be uncomfortable because someone watches them sleep.

The Statistics

Some interesting statistics about sleep apnea include:

  • 18 million Americans have moderate to severe apnea
  • 75% of patients with sleep apnea are unaware that they have the condition

The warning signs of sleep apnea include:

  • Waking up tired
  • Dozing off during the day, even in bright daylight

The biggest concern:

Sleep apnea can be fatal. When sleep apnea occurs, the brain does not get sufficient oxygen. When this happens throughout the night, the risk of having a stroke is four times greater than someone without sleep apnea.

An Updated Process

There is a new home sleep test, manufactured by NovaSom, which eliminates hospitalization. Instead of someone watching the patient sleep, the test is done in the privacy of the patient’s home.

How it Works:

  • The home test is done over three nights
  • The equipment is mailed to the patient’s home and also returned by mail. It includes: a belt clipped around the waist, a blood oxygen sensor worn on the finger, a breath sensor hooked over the ear and right under the patient’s nose and a computer modem sized box, which is worn on the arm (all the devices plug into this box)
  • The patient wires on the device, about a 15 minute process
  • While the equipment recharges each morning, it sends the previous night’s collected data to NovaSom for analysis

The Benefits of the Home Test

The cost of a home test is dramatically less than the traditional hospital-based test. The home sleep test cost averages $300 versus the hospital cost of about $3000.

The testing device is more portable so allows the patient to turn onto either side to sleep. In the hospital, patients are restricted to sleeping only on their back because of the equipment configuration.

If a piece of equipment comes loose, there is an audible reminder to check it for proper placement.

What the Home Test Does Not Do

The NovaSom home test does not record brain waves or activity. The hospital-based test does record these. What is the concern?

A home sleep apnea test can be inaccurate if the patient lies awake all night staring into the darkness because the brain waves are an indication of whether they are actually asleep or not. While lying awake, sleep apnea is not a problem so this could give an inaccurate assessment of the patient.

Who Should Not Use the Home Test?

Those with some medical conditions are not candidates for the home test. They include:

  • Heart failure
  • Emphysema
  • Seizures

The Results

Sleep apnea is measured by the number of times a person stops or almost stops breathing for at least 10 seconds per hour. The data collected represents the following results:

  • Less than 5 times is minimal
  • 5 to 15 times is mild
  • 15 to 30 times is moderate
  • Over 30 times is severe

When apnea occurs, the oxygen level in the body drops significantly. The normal oxygen level is at least 90%. With sleep apnea, it can drop into the 70% range.

The equipment also monitors snoring. In this case, snoring is qualified as any loud breathing, not just the traditional snoring sound. The NovaSom monitor has a very sound sensitive microphone.

Some sleep specialists project that hospital-based sleep apnea tests derive higher rates of the condition because the patient has to sleep on their back to accommodate the equipment. This back-lying position further closes an already narrow upper airway.

Treatment Options After Diagnosis

The treatment options for sleep apnea include:

  • Using a continuous positive airway pressure (CPAP) machine at night that forces air into the lungs while the patient sleeps
  • Losing weight
  • Drink less alcohol
  • Go to bed earlier

The treatment downsides include:

Patients dislike wearing the CPAP; it is cumbersome and restrictive

So what really works? Lifestyle changes that include weight management and less alcohol intake are key factors in reducing sleep apnea.

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Food Labels Explained

September 9th, 2014  |  The Blog

Who reads food labels anyway? Actually, according to a recent survey, less than 50% of Americans actually regularly read food labels.

Nutrition (food) labels tell the story. They are an important source of information that every consumer should read. It is essential to know how to read, but more importantly, how to understand the information on a food label.


The U.S. Food and Drug Administration (FDA) controls and updates any and all changes made to food labels. They have recently made some changes in an effort to simplify the standard food labels.

The Changes

The upcoming FDA-approved changes to food labels will include:

  • A larger, bolder print for easy reading
  • Larger, more realistic serving sizes rather than the standard ? cup serving size that no one follows
  • Added sugar amounts, which delineates natural sugar (as in fruit) from processed or added sugars like honey, brown sugar, molasses and agave. Each teaspoon of processed sugar contains additional 15 calories
  • Potassium content
  • Vitamin D content

Now, What Will be Removed From the Label?

Calories from fat will be removed because the type of fat is more important than the amount of fat.

What They Say

In addition to the aforementioned changes, the other information listed on food labels includes:

  • Total fat per serving
  • Saturated and trans-fat amounts, which should be a low as possible to prevent clogging arteries
  • Fiber
  • Sodium
  • Calcium
  • Protein is listed as grams per serving. Interestingly, to find the recommended daily intake of protein, the average person should divide their body weight (pounds) in half to reach the number of grams they need

The percentage of each content item (such as protein, fiber or potassium), which an individual needs on a daily basis, and the amount that each serving of the food contains is listed beside the item on the label.

It is important to disregard the information on the front of the package labeling as being a factual guide for the nutrition content. The front of most packaging is designed to catch the consumer?s attention, not give solid nutrition facts about the food item. Examples of the misleading labeling include descriptions like light, healthy, low-fat, all natural and 100% natural.

Important Quirky Facts to Remember

Some food items (like cereal) list the serving size by weight. Given that, the serving size for healthy cereals such as Cheerios looks much larger than that of a crunchy, sweeter, albeit healthy, granola. It is important to watch the serving size in items such as this.

Individual serving-size containers definitely help the consumer with portion control and their quest to limit overeating.

Some products, like a 20-ounce soda and a bag of crunchy, salty snacks, will show calories per bottle or bag. Many consumers currently think that one serving is the entire package, especially when the item is snack-sized. This is a misleading notion because even a snack-sized bag can contain 2 or 3 servings. Be sure to read the label.

Food labels contain a lot of information that goes unread. Watching the daily intake of each component listed on a food label will lead to healthier eating and, ultimately, help with overall wellness in most consumers.

Bon appetit!

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The Benefits of Eating Nuts During Pregnancy

September 3rd, 2014  |  The Blog

There has been a significant rise in childhood food allergies, especially nuts, over the past generation. This has prompted many studies about whether or not a pregnant woman should include nuts in her diet or not. The question remains unanswered, despite the research findings.

Earlier Philosophy

In years past, physicians used to believe that the best way to reverse the up-ticking trend in food allergies was to have babies avoid exposure to the popular allergens like nuts while in utero and during the first few years of life. Women were encouraged to avoid eating peanuts and tree nuts, even if they have no personal allergy.

The Updated Nut Allergy Theory

The previous practice and benefits of avoiding nuts during pregnancy has been somewhat disproved.

Current research, done by Boston Children’s Hospital, finds that babies born to women who consumed peanuts, almonds or other nuts on a daily basis during pregnancy are 30% less likely to develop peanut or tree nut allergies than those whose mother rarely ate nuts during pregnancy.

While the study shows strong support for pregnant women eating nuts, the study leaders have not made a firm declaration to change the universal practice of nut avoidance.

The Research

Women with and without nut allergies themselves were studied in the research.

Babies born to women with nut allergies who ate safe nuts during pregnancy?or those they were not allergic to nuts have a slight increase in nut allergies. It proved to be a non-significant increase. The data was compared to the statistics found in women with nut allergies who ate no nuts at all during their pregnancy.

The research is inconclusive with regard to a firm recommendation as to whether or not women should eat nuts during their pregnancy to protect their babies. The one conclusion the study derived is that women should not be afraid to eat nuts during their pregnancy, if they wish to do so.

It is important to note that peanuts are a good source of protein and also provides folic acid in the woman’s diet. Folic acid is important to prevent neural tube defects in the unborn. There are clear and present benefits to eating nuts, including peanuts, while pregnant.

The decision to be a nut eater or a nut avoider is left up to each woman during her pregnancy. Medical input from the attending obstetrician and involved pediatrician will help make the decision about whether to imbibe or not.

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Identifying Early Symptoms of Parkinson’s Disease

August 25th, 2014  |  The Blog

Parkinson’s disease (PD) is a progressive nervous system disorder. It slowly and adversely affects a person’s movement. PD also:

  • Causes resting tremors
  • Creates muscle rigidity
  • Affects speech, sometimes making it inaudible and slurred
  • Causes a blank facial expression

Medications, which have many potential and potent side effects, are currently used to control the symptoms of PD. There is no cure for Parkinson’s disease.

Hyposmia is a Clue

Interestingly, almost all patients with PD have a decreased sense of smell or hyposmia. This is one of the first clinical symptoms of the disease, although not fully recognized or fully evaluated by the medical community as a whole.

It is important to note that not everyone with a decreased sense of smell has or develops Parkinson’s disease. There are many other causes that can make a patient lose their sense of smell.

New Diagnostic Tools for Parkinson’s Disease

Once hyposmia is established in the clinical setting, further testing is available to determine if the patient is on the path to developing PD. These studies will help to identify patients who will likely develop clinical symptoms of PD. The tests include:

  • Olfactory or smell testing
  • Dopamine transporter (DaT) imaging

The single photon emission computed tomography (DAT-SPECT) is done after DaTscan or I-ioflupane in injected into the patient’s vein to enhance imaging. The DaTscan is visualized and recorded by a special gamma camera.

The U.S. Food and Drug Administration (FDA) have approved DaTscan, a radiopharmaceutical agent. The side effects of this agent include:

  • Headache
  • Dizziness
  • Increased appetite
  • Uneasy or crawling feeling under the skin

Those with a DATdeficiency went on to develop PD in 61% of those tested. Their clinical symptoms developed within four years of testing.

The Benefits of Knowing

The clinical application of the new diagnostic tools remains limited to research-only casess at this time. It remains to be determined if the general population who appears to be at risk of developing PD, according to testing outcomes, would benefit from medication treatment trials. The medications would provide neuro-preventive potential to those at risk.

The International Parkinson’s and Movement Disorder Society (MDS) speculates that treating patients in neuro-protective medication trials will have greater success in treating PD than waiting to treat those who present for treatment with clinical features (tremors, gait issues, inability to swing arms when walking, blank facial expression) of Parkinson’s disease.

One Caveat to the Story

There is also research afoot regarding whether there is a link between hyposmia and Alzheimer’s disease. Currently, the loss of smell in patients suspected of developing Alzheimer’s disease leads to further cognitive testing to solidify a positive diagnosis.

Loss of smell is associated with the first cranial nerve, which is one of the first points impacted by cognitive decline.

Again, early diagnosis of the disease would support earlier treatment intervention to slow the process. Medications are especially helpful in treating early symptoms of Alzheimer’s disease.

More research on the subjects, both Parkinson’s disease and Alzheimer’s disease, is pending.

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A Concern for Hysterectomy Patients

August 11th, 2014  |  The Blog

A hysterectomy is done for a variety of medical reasons. Sometimes it is done to remove fibroids, endometriosis or for other reasons. There might be a cancer diagnosis or not.

It is important to note that this blog discussion focuses on laproscopic hysterectomies, not the traditional open abdominal surgery.

Laproscopic vs. Traditional Open Surgery

Open abdominal surgery requires a 3 to 7-inch incision. There is a longer recovery than laproscopic surgery but it allows the uterus to be removed intact.

Laproscopic surgery is done through several tiny incisions on the abdomen. It allows faster recovery than traditional open surgery. The uterus or fibroids must be cut into small pieces, which are then removed through the tiny incisions on the abdomen.

The Equipment

Recent research shows that a surgical device used during a laparoscopic hysterectomy might spread cancer in the patient’s body. The American Medical Association (AMA) has published a report about the device and called it?risky. The U.S. Food and Drug Administration (FDA) advised physicians to stop using it.

The device, which is causing all of the concern, is a laparoscopic power morcellator. A morcellator utilizes spinning blades to slice uterine fibroids or the entire uterus into fragments that can be removed through the small laproscopic incisions.

The morcellator has been in use in the U.S.for about 20 years but there is very little data about it available prior to the current cancer concerns.

The Problem

A recent study found that 1 in 368 women who have a hysterectomy actually have hidden or undiagnosed uterine cancer. The most common cancers of concern are uterine sarcoma and endometrial cancer.

The morcellator can spread previously undetected cancerous tissue inside the body. When the uterus or other tissue is morcellated, pieces of the tissue can errantly remain in the body. If they are cancerous, this can spread the disease.

A Suggested Solution

If the uterus is placed inside a protective bag before morcellating, stray tissue pieces remain contained and cannot escape to other areas of the body. There are some U.S. hospitals that have recently started this extra precautionary measure.

The Decision

Supporters of the morcellator argue that banning it is the wrong decision. They say that more women will have unnecessary traditional abdominal hysterectomies, which result in more significant scars, longer recovery time and the risk of more surgical complications.

Opponents of the device argue that the risk of using the morcellator is too high for an elective procedure. They say that there are alternatives to using the device, which should be considered.

Interestingly, in a recent study of 230,000 laparoscopic or minimally invasive hysterectomies, only 16% of them were performed with the morcellator after the safety of the device came into question.

The largest manufacturer of the device is Johnson & Johnson. The company recently suspended sales of the morcellator based on the FDA recommendation.

The FDA is considering whether to restrict or possibly ban the use of morcellators. A decision will be announced within this year.

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Ebola Explained

August 6th, 2014  |  The Blog

Ebola is a deadly virus. It is named for the Ebola River that runs close to where the first cases of the illness were identified in 1976.

Where is the Outbreak?

The virus originally presented in Sudan and the Democratic Republic of the Congo.

Currently, there is an Ebola outbreak in West Africa including the countries of Guinea, Liberia, Nigeria and Sierra Leone.

According to healthcare authorities, the virus is highly unlikely to be a credible threat on U.S. soil.

How Deadly is the Virus?

According to the World Health Organization (WHO), there are over 1,600 cases of the illness in West Africa. Of those cases, nearly 900 have died.

There are five known strains of the virus. The current culprit is Ebola Zaire.

About 90% of people, depending upon the reporting agency, who contract the illness die in underdeveloped countries. The U.S. Centers for Disease Control (CDC) states that the variation in the mortality rate reflects the benefits of early medical intervention. It is still unknown if modern medical care in a U.S. intensive care unit would make a positive difference in the mortality rate.

Patients typically die in 7 to 14 days after the symptoms first occur.

Spreading the Virus

The Ebola virus is not airborne. It takes vey close contact with an infected person in advanced stages to contract the illness. It can spread from infected animals (fruit bats, chimpanzees, gorillas, forest antelope and monkeys) or humans.

The virus spreads by close contact with skin and bodily fluids. Almost all bodily fluid can transmit the virus. They include:

  • Blood
  • Vomitus
  • Feces
  • Urine
  • Sweat
  • Saliva
  • Breast milk
  • Tears

Kissing and sex can transmit Ebola. Patients with the illness are not typically well enough to engage in such activities, according to authorities.

The incubation time for Ebola, when symptoms occur after being exposed to the virus, is 14 to 21 days.

Symptoms of the Illness

Initially, Ebola presents with symptoms of a bad case of the flu. These include:

  • High fever
  • Muscle pain
  • Headache
  • Sore throat
  • Intense weakness

More serious symptoms quickly develop, which include:

  • Vomiting
  • Diarrhea
  • Internal bleeding/hemorrhaging
  • External bleeding/hemorrhaging
  • Kidney failure
  • Liver failure

The virus can be in a person?s system for three weeks before they have any outward symptoms. If they survive the illness, the virus can stay in the body for several weeks after they recover.

Vaccine or Cure Availability

Neither option, a vaccine nor a cure, is currently available.

Treatment options for Ebola are supportive in nature. Support measures include the following: IV fluids including electrolyte replacement, medications to control blood pressure, mechanical ventilation and transfusions.

Until the current outbreak, drug companies did not prioritize an Ebola vaccine or cure. The recent crisis has brought the need to the forefront in the medical field and has accelerated the much-needed process.

Preventing the Spread

Contact precautions are necessary, including gowns, gloves and eye protection. Universal precautions, which covers treating all bodily fluids and blood as if they are infected, are very important. Hand washing is always an important precautionary measure.

Educating the public, in the highly affected areas, to avoid close contact with sick people and dead bodies is critical to preventing the spread of the disease.

The risk of the disease spreading to the U.S. is highly unlikely. The mere distance from West Africa to the U.S. is significant enough that a sick person would have trouble making the trip.

Declaring the Outbreak Over

Public health officials will declare the Ebola outbreak in West Africa to be over in 6 weeks after the last case is diagnosed. This can take 3 to 6 months, according to the CDC.

The Future

The National Institutes of Health (NIH) have been developing an Ebola vaccine for several years. They plan to begin an early stage vaccine trial in September 2014.

Depending upon the vaccine study results, which are expected by January 2015, it could be available to health workers in affected African countries sometime in 2015.


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Afrezza: Inhaled Insulin for Treating Diabetes

July 30th, 2014  |  The Blog

Treatment options for diabetes are ever evolving. Those with type 1 or type 2 diabetes have a new U.S. Food and Drug Administration (FDA) approved treatment option, inhaled insulin. The FDA approval is for safety and effectiveness of the drug.

The new drug, Afrezza, is a fast-acting insulin, which requires no needles. The inhaled drug is taken before each meal. Afrezza does not replace injected long-acting insulin for those patients who need that form of treatment.

It is important to note that there was an inhaled insulin called Exubera, which was FDA approved in 2006. The manufacturer withdrew it from the market in 2007 due to poor sales numbers and an overly complicated administration process for the patient.

Afrezza is the new and improved inhaled insulin.

How It Works

Afrezza is inhaled and absorbed through the cells in the lungs and into the blood stream.

The drug peaks in the blood about 15 to 20 minutes after it is inhaled. This is a difference compared to injected insulin, which peaks about an hour after it is taken.

Afrezza also clears faster from the body than injected insulin. After it quickly peaks, the drug is gone from the body in 2 to 3 hours. This is a difference from injected insulin, which remains in the body for about 4 hours after it is taken. Manufacturers of Afrezza tout this as a major benefit citing that Afrezza?s rapid response and rapid exit from the body mimic a normally functioning pancreas.

How it is Administered

A powdered dose, in an individual cartridge, of Afrezza is administered in a small, whistle-sized inhaler. Each cartridge contains one single dose of the drug.

It is easy to teach a patient how to use the inhaler to administer the drug.

Benefits of Afrezza

There are a few main benefits to this inhaled insulin product, which include:

  • No needles involved; 10% to 15% of insulin dependent patients are adverse to needles
  • Controls blood sugar equally as well as injected insulin, according to research studies
  • Less likely to cause a very low blood sugar, which is a common complication of insulin
  • Less weight gain, probably due to the short length of time the medication is in the body
  • Patients who do not have good blood sugar control using oral medications have better regulation using inhaled insulin
  • Patients might need less insulin than the traditional injected insulin

The Cost

The manufacturer compares the cost of inhaled insulin to the cost of the fast-acting and common pen form insulin. The cost of a fast-acting pen insulin costs $270 a month for those who need an average of 30 units of insulin a day, before health insurance coverage.

Side Effects of the Drug

The most commonly reported side effects of Afrezza are:

  • Low blood sugar
  • Cough
  • Throat pain
  • Throat irritation

The drug warnings also include the possibility of sudden chest tightening or acute bronchospasm. This potential side effect makes Afrezza be contraindicated for patients with asthma, COPD or those who smoke.

Some physicians are concerned about the effect of Afrezza on lung tissue, the mouth and esophagus.?The FDA is investigating whether Afrezza creates any potential risk of lung cancer. This is an important factor in the success of the drug.

Afrezza is not recommended to treat diabetic ketoacidosis, which is a serious complication of diabetes. Diabetic ketoacidosis is a condition in which the body makes high levels of ketones or blood acids.

In Closing

Afrezza is not yet available to the general patient population. With the FDA approval, it will be available in the not-to-distant future, according to the manufacturer MannKind, who is seeking a pharmaceutical partner in the marketing effort.

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