Fertility After Pediatric Cancer Treatment » Nursing Jobs Blog – Nurses Insights at Nursing Jobs.org

Fertility After Pediatric Cancer Treatment

February 16th, 2016  |  The Blog

An estimated 75% of children diagnosed with cancer survive into adulthood. The statistics are climbing higher but there is concern about children having children after cancer treatment. Their fertility is a real concern.

What Happens When Children Undergo Cancer Treatment?

Here are some facts about children undergoing cancer treatment:

Girls

Ovarian function is impaired. Specifically, the number of eggs within the ovaries is reduced, according to chief medical officer at Dana Farber/Boston Children’s Cancer and Blood Disorders Center, Dr. Lisa Diller. Basically, cancer treatment causes ovaries to age significantly. Those who have had cancer treatment and are now 20-years old, have the ovarian function of a 35 to 40-year old woman.

Boys

According to Dr. Richard Yu, MD, PhD, a urologist in Boston Children’s Hospital Department of Urology, chemotherapy and radiation used to treat childhood cancer can obliterate the sperm stem cells in the testes, much like the treatments affect a girl’s ovaries and eggs.

The Problem

The best case scenario would be for a child who is about to undergo treatment to bank their eggs or sperm. Patients diagnosed with cancer before puberty do not have mature eggs or sperm to bank before they begin cancer treatment.

Alternative Solutions Regarding Infertility?

Experimental procedures are in place as alternatives to banking eggs and sperm. For girls, ovarian tissue preservation and for boys, testicular tissue preservation is on the horizon. The effectiveness of both alternatives remains to be determined for the long-term.

Boys

The procedure to collect sperm stem cells, which can be re-implanted at a later time or stimulated to develop into mature sperm, is currently developed but still experimental.

Girls

Ovarian tissue preservation is more complicated than sperm stem cell preservation. The current downsides to this alternative solution are:

  • It is very experimental
  • It is invasive for the female child
  • The cost is prohibitive, in the thousands of dollars
  • Not all retrieved tissue survives the freezing process
  • It is an unknown time frame for how long the tissue can remain frozen
  • If any cancer cells are present in the tissue, it cannot be re-implanted because cancer could be reintroduced into the patient

There is an ovarian marker, anti-Mullerian hormone (AMH), which can indicate girls who are at high risk for infertility after cancer treatment. These girls would potentially reap the benefit of egg or ovarian tissue banking.

How AHM Works

AMH levels are lower if a child has longer or more aggressive cancer treatment. AMH is a good indicator of ovarian reserve in adult females and also helps to look at the fertility potential for pediatric patients.

Boys

Biopsies are used to identify new sperm stem cell markers. The hope of researchers is that cancerous cells and healthy cell can be separated and better procedures to coax stem cells to mature will be identified.

The Long-Term Outcome

By the time these pediatric patients are adults, the hope is that the technology linked to these experimental procedures to preserve future fertility will have evolved. There needs to be successful technology to:

  • Re-implant tissue
  • Stimulate tissue
  • Mature eggs in a lab without re-implanting
  • Mature sperm in a lab without re-implanting

For this alternative procedure to actually be effective and successful, the technology to reuse the frozen tissue needs to catch-up with the procedures used to retrieve them. If the technology evolves over the next 10 to 20 years, those patients who banked eggs or sperm will benefit greatly with regard to infertility. Without banking eggs or sperm, there will be little to no chance of fertility in the future. It is a gamble but one that some feel is worth risking.

nburgess
About nburgess

No Responses to “Fertility After Pediatric Cancer Treatment”

  • ???????? said on February 20th, 2017 at 9:27 pm

    1? ?????????????????????,?????????;????????????????????,?????6%,??85?????”????????????”??,?????????????????????????????????,2011?,????????????????????????????????,2013??11???

  • cvgbcgzvyr said on February 20th, 2017 at 9:28 pm

    Fertility After Pediatric Cancer Treatment ? Nursing Jobs Blog – Nurses Insights at Nursing Jobs.org
    acvgbcgzvyr
    [url=http://www.g19tyj0ny30v2j1wsm6j0f13l29a24k8s.org/]ucvgbcgzvyr[/url]
    cvgbcgzvyr http://www.g19tyj0ny30v2j1wsm6j0f13l29a24k8s.org/

  • reverse cell phone lookup said on February 20th, 2017 at 9:52 pm

    cell phone lookup name reverse cell phone number lookup
    reverse lookup free cell phone

  • Printed Paper Napkin said on February 20th, 2017 at 10:15 pm

    Fertility After Pediatric Cancer Treatment ? Nursing Jobs Blog – Nurses Insights at Nursing Jobs.org

  • http://perola.itis.ac.mz/blogs/post/77 said on February 20th, 2017 at 11:46 pm

    good article,it is useful to me and others to know about this items,please just keep it….

  • Lead Capture Templates said on February 21st, 2017 at 1:26 am

    Ahaa, its pleasant conversation concerning this piece of writing here at this web site, I have read
    all that, so at this time me also commenting here.

  • Led Display News said on February 21st, 2017 at 1:29 am

    Fertility After Pediatric Cancer Treatment ? Nursing Jobs Blog – Nurses Insights at Nursing Jobs.org

  • FGMNT. said on February 21st, 2017 at 1:54 am

    I like the helpful information you provide in your articles.

    I’ll bookmark your blog and check again here frequently.

    I’m quite certain I will learn many new stuff right here!
    Best of luck for the next!

  • Cheap NFL Jerseys China said on February 21st, 2017 at 2:13 am

    Having a watch to acquire my CompTIA A+ certification, I needed to move two organization related a+ exams. More than merely learning a few methods on keeping your car looking great, it’ll be necessary for you to be aware of some of the bad methods to steer clear of.99 and $1. The person has to see to it that he has enough budget in paying for the session. Acquire discover of the, and make sure you put advertisements that healthy what these are seeking for.

  • tour agent said on February 21st, 2017 at 3:12 am

    I’m gone to tell my little brother, that he should also
    go to see this website on regular basis to take updated from
    hottest gossip.

  • ???????????? said on February 21st, 2017 at 3:45 am

    FuturEco?????2010????????????WYEC 108???????????????”?????????”???????????”????”????”????”???????????????(????????)?????(???????????)?,????????????????? ?????????2015-2020????????????????????????????? ???????????????,?????????????????????

Add Your Comments

 
Copyright © 1999-2014 Nursing Jobs, LLC. All Rights Reserved.
Call 888.613.8844 (M-F, 7-5 Pacific)

Send a message